ANALGESIC TEST OF COMBINATION OF ETHANOL EXTRACT OF WULUH BLIMBING (Averrhoa bilimbi L.) AND Moringa (Moringae Oliferae L.) LEAF LEAVES IN MALE MOUSES, Swiss Webster Strain

Abstract

Analgesic drugs are used to reduce and relieve pain without loss of consciousness. The plants
used as analgesics were Moringa leaves (Moringae Oliferae L.) and starfruit leaves (Averrhoa
Bilimbi L.), because these two plants showed the presence of compounds such as flavonoids,
alkaloids, saponins, and tannins. The aim of the study was to determine the analgesic effect.
In Moringa leaf and star fruit leaf male Swiss Webster mice, the combined dose of 2:2 and
800 mg of Moringa oleifera extract and 1000 mg of star fruit extract were reduced in each
rat. The method used to test the analgesic activity is the hot plate method. The responses of
mice before administration and 0, 15, 30, 45, and 60 minutes after administration were
observed, and the data were analyzed by ANOVA and LSD tests. Moringa leaf extract and
belimbing wuluh leaf extract at a combined dose of 1:1, 2:2, 2:1 had analgesic effect on male
Swiss Webster strain male mice. The three best combinations that gave analgesic effect were
at a combination of 2:2 doses and 800mg and 1000mg doses, the average tensile protection
results obtained were 0%, 65; 06%, 13; 65%, -15.29%, 18; 33%.